Helton's daughter threw out the first pitch as his wife, younger daughter and good friend Peyton Manning watched from the side. At the end of it all, the Rockies presented Helton with a horse to ride on his Colorado ranch.
Once the game started, Helton started his own show, hitting a fastball from Peavy into the right-field seats in the second. He also had an RBI on a sacrifice fly and an RBI double off the wall in left.
Shane Victorino and Middlebrooks rained on Helton's celebration. Victorino broke a 4-all tie in the fourth with his three-run homer to left. Middlebrooks followed an inning later with a three-run homer over the scoreboard in right field to make it 10-4.
That was more than enough for Peavy, who settled into a groove after his rocky start. He is now 4-1 with a 4.03 ERA since being acquired from the Chicago White Sox on July 30.
Victorino, Peavy and Middlebrooks were among a dozen or so Red Sox players who hung around the visitors' dugout to extend their congratulations to Helton, who took a post-game farewell lap around the stadium.
"Oh yeah, I shook his hand," Middlebrooks said. "I wasn't going to miss it. It was pretty special, special to just be in the stadium tonight, especially in that first at bat. That first homer gave you goose bumps even on the opposing side. It was a pretty special night all around."
Peavy said he always admired and respected the way Helton played the game.
"I just wanted him to know how much I appreciated the way he went about things," Peavy said. "Me and Todd have had many many matchups like we had tonight, and I'm not going to miss him in retirement on the baseball field."
Jarrod Saltalamacchia had four hits and drove in three runs for Boston.
NOTES: Red Sox 1B Mike Napoli (left foot) sat out a fourth straight game. ... After a day off, RHP Clay Buchholz (11-1) will pitch for Boston on Friday in Baltimore.