The interception was Reeves' third of the season.
Soon after, Flanders scored his first touchdown on an 8-yard run.
After the Wolves failed to advance on the next series, Antonio Martin blocked a Santa Fe punt to give the Bombers the ball at the 1, setting up another Flanders score, and Midwest City (3-0) began pulling away.
The blocked kick was the Bombers' fifth of the season.
“I lined up, and there wasn't anybody in front of me,” Martin said. “Oh yeah, I thought I had a good chance to get it.”
Martin also blocked a kick in the Bombers' season-opening win over Del City.
Just before half, the Bombers made it 20-0 when Zac Brannon pulled down Joel Davis' 17-yard pass with less than two seconds remaining the half.
“We don't pass it a lot, but when we do need to, Joel can get it done,” Flanders said.