The touchdown grab was his 22nd of his career, which passed Dan Stricker's (1999-2002) previous program record. He also is the new owner of the most receiving yards in school history with 2,996, passing Boo Mitchell's (1985-88).
When asked about the records, Matthews said, "it doesn't matter." Instead, he and his teammates agreed to focus on recovering from the loss.
"We are 0-1 but tomorrow we are going to be back 0-0," Matthews said. "I don't want to talk about bye weeks, I don't believe in bye weeks because I believe every day is a game. We got 2-3 games in practice, that's where you win the games."
Wesley Tate added a career-night for the Commodores with six catches and 57 yards. The running back rushed for his third touchdown of the season in the second quarter as well.
Missouri, which lost at home last season 19-15 to Vanderbilt, is off to the fifth 5-0 start in coach Gary Pinkel 13 seasons. Their defense has led the way.
The Tigers have 11 interceptions so far this season, behind only Virginia Tech. The interception Saturday was the 35th consecutive game with a takeaway.
"That interception we had was huge — the time, where the ball ended up and the field position we had with it," Pinkel said. "Every defense in the nation wants turnovers and they all work hard at it. Sometimes it gets contagious and you make things happen."
Missouri travels to Georgia next week.