Marquette, meanwhile, made just six baskets as a team in the first half, shooting 20 percent from the floor. They went into the locker room trailing 62-17 at halftime.
UConn did not let up much in the second half, leading by as many as 58 points. The Huskies were 15 of 23 from 3-point range and shot 55 percent from the floor.
Stefanie Dolson returned to the UConn lineup after missing the St. John's game with a stomach bug and chipped in with 15 points. With the junior center on the bench, the Red Storm matched the Huskies, scoring 26 points in the paint. UConn had 30 inside points Tuesday, to just 14 for Marquette.
"It was something that I don't want to go through again, cause it was really weird," Dolson said of sitting out a game. "It felt good to be out there and playing with the team, and playing the way we did."
Katherine Plouffe, Marquette's leading scorer, was held to just four points. She didn't score in the teams' first meeting this season, an 85-51 UConn win on Jan. 12.
The game was the first in a three-game road trip for Marquette, which heads to Villanova and Cincinnati before going home to host No. 2 Notre Dame on Feb. 17.
UConn played without backup point guard Brianna Banks, who will miss the remainder of the season with a torn anterior cruciate ligament in her right leg.
Banks suffered the injury during the first half of the Huskies' 71-65 victory over St. John's on Saturday. The school released the diagnosis on Monday and said surgery would be scheduled in the coming weeks. The sophomore from Newnan, Ga. had been averaging 7.3 points and 1.7 assists in just over 17 minutes per game. She was shooting 47.9 percent from the field.