Bachman injured a groin lunging for a puck with six minutes to play in the opening frame and had to be helped off the ice. Jason LaBarbera replaced him in the Edmonton net.
Detroit made it 3-0 seven minutes into the second period when Daniel Alfredsson dished the puck to Kindl at the top of the right circle for a hard shot that blew past LaBarbera.
The Red Wings outshot the Oilers 21-10 through the first 40 minutes.
Detroit went up by four goals eight minutes into the third. A wraparound attempt popped free in front of the net, and Andersson score his second of the season.
Two minutes later it was 5-0 as Henrik Zetterberg hooked behind the net on the power play and fed the puck to Bertuzzi at the back door. Bertuzzi's 21 career goals against Edmonton are the most he has scored against a team.
"It's frustrating, there is not much else to be said," Oilers center Sam Gagner said. "Our compete level wasn't high enough and we weren't sharp to start the game."
The Red Wings will wrap up a four-game Western Canada swing in Winnipeg on Monday. Edmonton will begin a four-game trip in Florida against the Panthers on Tuesday.
NOTES: The game was the first of two meetings between the teams this season. Detroit won all three meetings last season, when both clubs were in the Western Conference, and is 7-0-5 in its last 12 visits to Edmonton. ... With Gustavsson out with a neck injury, the 21-year-old Mrazek got the third start of his NHL career. Howard had the night off after playing Friday at Calgary. ... Edmonton D Justin Schultz was out with a groin injury and forward David Perron missed his second game with a neck injury. D Philip Larsen made his Oilers debut, and F Ryan Hamilton returned for the first time since sustaining a knee injury on Oct. 7. ... Red Wings forward Johan Franzen (illness) left Friday's game at Calgary and sat out against the Oilers.
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