"I knew after the first question," she said in the taped interview. "I turned to my son after 50 minutes, and I gave him a nudge, and I said, 'It's 100 to zero right now.'"
Mrs. Romney sharply disputed accusations from Obama's campaign that her husband failed to tell the truth during the debate.
"It's sort of like someone that, you know, in the sandbox that, like, lost the game. And they're just going to kick sand in someone's face and say, 'You liar,'" she said. "I mean, it's like they lost, and so now they just are going to say, 'OK, the game, you know, we didn't like the game.' So it's to me, it's poor sportsmanship."
She said she hopes her husband's performance leads more women to support his campaign because so many of them approach her on the campaign trail to say how they are struggling in the current economy.
"These are real people out there. They're not numbers to Mitt and I anymore," she said. "And I hope that came across, that why Mitt's running, is to make the economic opportunities for people that are out there that are really, really desperate."
Later in the day, Mrs. Romney flew to Florida to tour the Moffitt Cancer Center in Tampa. Mrs. Romney, who also overcame a bout with breast cancer, also made bracelets with cancer survivors at the facility.