Iwakuma had another strong outing for Seattle. He allowed two runs and two hits over eight innings. He struck out eight.
"We fought — did everything we could. It just didn't work out," Pierzynski said.
The Rangers now face a double-header against the Arizona Diamonbacks on Monday with a depleted bullpen. Washington said Neal Cotts will be unavailable after throwing 2 1-3 innings Sunday. Joe Nathan and Tanner Scheppers are also likely unavailable.
"You can't control the way a baseball game goes so we'll figure it out tomorrow," Washington said. "Hopefully (Martin) Perez and (Yu) Darvish can give us nine innings in each game and everything works out good."
Notes: Profar is the youngest player to hit a leadoff home run (20 years, 95 days) since Lou Klimchock (18 years, 348 days) of the Kansas City Athletics homered on Sept. 28, 1958, against the Chicago White Sox. ... Nathan had his streak of 36 consecutive saves on the road snapped with Ibanez's tying home run in the 11th inning. Nathan had converted all 31 save opportunities on the road since joining the Rangers last year. ... Mariners 1B Justin Smoak is day to day after straining an oblique Saturday night. Morales started in his place. Michael Morse also is expected to see time at first base in Smoak's absence. ... Mariners RHP Yoervis Medina earned his first major league victory.