Doing so would mean the Cowboys have won their 11th NCAA title.
OSU captured the Ping/Golfweek Preview at Inverness by a record 16 shots last fall, with freshman Morgan Hoffmann finishing as co-medalist.
The top-ranked Cowboys return to Inverness today for the new-look NCAA Championships, which are under a new format.
No longer is the tournament 72 holes of stroke play to determine the team and individual champions.
The field will now play 54 holes, with the medalist being crowned after the first three rounds. The top eight teams will then compete in a single-elimination, match-play bracket to determine the team champion.
This will be the first time since 1965 the team winner will not be determined by total strokes.
The Cowboys will extend their record streak of consecutive NCAA appearances to 63.
They have placed in the top 5 in 48 of their previous 62 appearances.
Though OSU starts two freshmen and two sophomores, the national title is within reach.
"We work each week to get better with that goal in mind,” sophomore Kevin Tway said.