INDIANAPOLIS (AP) — Andrew Luck threw for three touchdowns and ran for another Sunday night, outplaying predecessor Peyton Manning in a 39-33 victory over the previously unbeaten Denver Broncos.
The victory ended the Broncos' 17-game regular-season winning streak in the first game Manning played against his former team since being released in March 2012.
Manning finished 29 of 49 for 386 yards with three TDs and one interception. He was sacked four times and tried desperately to rally the Broncos late.
But the Colts (5-2) took advantage of his and Denver's uncharacteristic mistakes.
Luck converted an early fumble into a TD pass. Indy got nine points out of a second-quarter strip sack, and Luck scored on a 10-yard run in the third quarter, a drive helped by a series of defensive penalties. When the Broncos (6-1) finally had a chance to tie it, Manning was intercepted.
Indianapolis has not lost consecutive games under Luck.
CHIEFS 17, TEXANS 16
KANSAS CITY, Mo. (AP) — Jamaal Charles ran for 86 yards and a touchdown, Alex Smith also ran for a score and the scrappy Chiefs held off the banged-up Houston to remain unbeaten.
The Chiefs were forced to punt the ball to Houston with 1:46 left in the game. But after Case Keenum threw an incompletion on first down, the young quarterback was stripped by linebacker Tamba Hali at his 2. Derrick Johnson recovered the fumble for the Chiefs.
Smith simply kneeled from there as time ran out, allowing Kansas City (7-0) to extend the second-best start in franchise history. The 2003 team began the season 9-0.
Keenum, making his first NFL start in place of the injured Matt Schaub, threw for 271 yards and a touchdown for the Texans (2-5). But he didn't get much help from his run game after Arian Foster left in the first quarter with a hamstring injury and did not return.
REDSKINS 45, BEARS 41
LANDOVER, Md. (AP) — Roy Helu's third touchdown, a 3-yard run with 45 seconds to play, lifted the Redskins.
Robert Griffin III completed 18 of 29 passes for 298 yards with two touchdowns and one interception for the Redskins (2-4), who have both of their wins against backup quarterbacks. This time it was Josh McCown, who entered in the second quarter after Jay Cutler left with a groin injury.
Griffin also ran 11 times for a season-high 84 yards against a defense depleted by injuries, but the breakout performance came from rookie tight end Jordan Reed, who caught nine passes for 134 yards and one touchdown.
McCown, playing in a regular-season game for the first time since the 2011 season, completed 14 of 20 passes for 204 yards with one touchdown. Matt Forte rushed for three touchdowns, Alshon Jeffrey had 105 yards receiving, and Devin Hester tied Deion Sanders' NFL record for return touchdowns with an 81-yard put runback for the Bears (4-3).
JETS 30, PATRIOTS 27, OT
EAST RUTHERFORD, N.J. (AP) — Nick Folk kicked a 42-yard field goal with 5:07 left in overtime. Folk got a second chance after he missed a 56-yarder moments earlier. But Chris Jones was called for unsportsmanlike conduct for pushing a teammate forward to try to block the kick, a new NFL rule.
New York, given new life, ran the ball three times to set up Folk's winner.
Geno Smith threw a touchdown pass and ran for another score as the Jets (4-3) topped Tom Brady and the Patriots (5-2). New England tied it at 27 with 16 seconds left in regulation on Stephen Gostkowski's 44-yard field goal.
New England had defeated New York in six straight regular-season meetings, and saw its 12-game winning streak against the AFC East end.
STEELERS 19, RAVENS 16
PITTSBURGH (AP) — Shaun Suisham drilled a 42-yard field goal with no time remaining. Suisham's fourth field goal of the day pushed the Steelers (2-4) to their second straight win.
Ben Roethlisberger completed 17 of 23 passes for 160 yards and a touchdown. He hit Antonio Brown for a pair of big gains on Pittsburgh's final drive, putting Suisham well within range to win it. Running back Le'Veon Bell ran for a season-high 93 yards on 19 carries.
Joe Flacco passed for 215 yards and a touchdown, but couldn't stop the defending Super Bowl champions (3-4) from losing for the third time in their last four games.
PACKERS 31, BROWNS 13
GREEN BAY, Wis. (AP) — Aaron Rodgers guided an undermanned offense with 260 yards and three touchdowns, and Eddie Lacy ran for another score.
Lacy finished with 82 yards, while tight end Jermichael Finley had a 10-yard touchdown catch in the first quarter before leaving with a neck injury. The team said he had movement in his extremities.
Green Bay (4-2) won its third straight game.
Rodgers finished 25 for 36 in methodically carving up Cleveland (3-4) despite already being without two of his top targets in injured receivers James Jones and Randall Cobb.
The defense took care of the rest against struggling quarterback Brandon Weeden, who was 17 for 42 for 149 yards. The Browns' Jordan Cameron caught a 2-yard touchdown pass in the fourth quarter.
49ERS 31, TITANS 17
NASHVILLE, Tenn. (AP) — Colin Kaepernick threw for 199 yards and ran for 68 and a touchdown. The 49ers (5-2) won their fourth straight before heading to London for a game with winless Jacksonville by jumping out to a 17-0 halftime lead. Frank Gore also ran for a pair of 1-yard TDs as San Francisco cruised.
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