"I didn't think we'd lose any," McGraw joked. "I'm a little disappointed."
The loss ended a six-game winning streak for Louisville (20-5, 8-3), its second longest Big East winning streak since joining the league in 2005-06.
Kayla McBride added 15 points, Jewell Loyd 12 points and nine rebounds, and Ariel Braker scored 10 for the Irish. Antonita Slaughter had 16 points and Shoni Schimmel had 13.
Although the game wasn't as exciting as the men's game, the crowd of 8,368 still got into the game, letting out a loud cheer when Loyd scored on a fastbreak layup to give the Irish an 85-60 lead and again when Madison Cable hit a 3-pointer to give the Irish a 90-62 advantage.
The win marked just the fourth time in 10 tries the home team has won in the series.
"That's a great win for us, to come in and play that well against a really good team," McGraw said.