Twice the two teams traded interceptions and Texas Tech got touchdowns after both of its picks.
Texas Tech gave up a season-high 281 yards rushing and a season-high five touchdowns on the ground.
The Cowboys tallied 492 total yards, the most the Red Raiders have given up all season.
It was the Cowboys fifth straight win over the Red Raiders. Oklahoma State is the first team to beat Texas Tech three straight times in Lubbock since Nebraska (1994, 1996 and 2000).
The Cowboys took a record crowd of 61,836 out of the game early, jumping out to a 21-0 lead in the first quarter. Oklahoma State converted touchdowns on a fumble by Amaro — his second in two games — and after a blocked punt.
The Cowboys first three scores came on two 1-yard touchdowns by Roland and a 6-yard pass from Chelf to Tracy Moore.
Texas Tech came into the game tied for ninth worst in turnovers in the nation with 19, including seven interceptions Webb.
Webb's first interception was negated three plays later. Chelf never saw defender Pete Robertson, who returned it 21 yards to pull Texas Tech within 28-17.
The freshman found receiver Eric Ward in the flat on about the Cowboys 35 and Ward raced up the near sideline and outran a defender for a 38-yard score to make it 21-10 on the first play of the second quarter. The Red Raiders cut the deficit to 28-24 when Kenny Williams scored on a 2-yard run with 2 minutes left in the half.
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