Chelf passed for 229 yards in his second career start. Walsh, who had what coach Mike Gundy called a season-ending injury four weeks ago, ran for one touchdown and threw for another out of a short-yardage package.
Anderson was on the receiving end of scoring passes of 60, 33 and 66 yards from Chelf and ended up with nearly three times his previous career-best of 64 yards receiving in a game.
Joseph Randle and Jeremy Smith each tacked on touchdown runs for Oklahoma State in the second half, and Quinn Sharp matched his career-long with a 51-yard field goal. Craig's punt block extended the lead to 59-14 early in the fourth quarter.
It wasn't the complete dominance as last season, when Oklahoma State was up 35-0 after the first quarter and 49-0 by halftime. But it wasn't far off.
"You're just trying to go out and win. It doesn't really matter how it happens," Chelf said. "They're a good team, but we came to play today with a lot of energy and wanted to send the seniors off right."
Doege threw a 2-yard TD pass to Tyson Williams with 15 seconds left before halftime, and the Red Raiders got the ball to start the second half. But Doege's second interception — directly into the arms of retreating defensive tackle James Castleman — ended that drive and any momentum for Tech.
Darrin Moore caught a late 7-yard touchdown pass from backup Michael Brewer and finished with 140 yards receiving for Texas Tech.
Since ending an unbeaten start by then-No. 5 West Virginia a month ago, the Red Raiders have lost three times and squeaked out a pair of wins in triple overtime and double overtime.
"I've got no problem with effort, how the guys go into each game and how they compete," Tuberville said. "It's just, it seems like we were our own worst enemy in a lot of ways tonight, in terms of just mentally not making a play, or mentally as a coach, putting a guy in a position to not have success. It's been a long eight games but we'll bounce back."
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