Tabitha Gerardot and Maegan Callaway each scored nine points for Valparaiso (3-6), which shot just 39 percent and didn't get into double digits until late in the first half.
Louisville bounced back big after Sunday's 48-47 loss to intrastate rival Kentucky. The Cardinals blew a 14-point second half lead and were stunned by Wildcats freshman Janee Thompson, who hit a game-winning 3-pointer with 8.4 seconds remaining.
Walz urged his team to move on quickly from that disappointment and focus on preparing for the upcoming Big East schedule. Considering how Sunday's error-prone game ended for the Cardinals, the immediate objective was correcting those mistakes.
Valparaiso meanwhile was coming off Tuesday's 82-73 win at IPFW that ended a five-game slide. The Crusaders shot 50 percent and converted 24 of 27 free throws in that game, a big improvement from their skid in which they shot just 103 of 306 (34 percent).
The Cardinals needed less than 3 minutes to put the Crusaders in another hole.
Louisville led 12-0 lead with 3-pointers comprising three of its first five baskets. The Cardinals followed with a 27-7 run en route to a 55-19 halftime lead, hitting 22 of 44 from the field including 6 of 11 from beyond the arc.
Slaughter contributed two of those 3's in scoring a team-high nine points in the half.
Walz chalked up Slaughter's recent play to "her focus, just how she approaches the game."
Defensively, she was part of a bigger starting lineup that overwhelmed the Crusaders. Valparaiso committed 15 turnovers leading to 25 points for Louisville, which turned the ball over just twice.