"We tried to deny, we tried to front and we went into a zone," Lobos coach Yvonne Sanchez said. "She's just that good."
Keller is in the lineup because of season-ending injuries to three of the Lobos' front line players, including sophomore Whitney Johnson and junior Ebony Walker.
Ogwumike, who blocked four shots, was 10 of 15 from the field in the first half as Stanford took a 40-21 lead. She left the game for good with 10:30 remaining to play.
"Chiney is one of the best post players in the nation if not the best," Sanchez said. "She has that curving hook shot that is almost impossible to defend and she's so strong with her dribble."
The Lobos, who had a two-game winning streak snapped, were within 7-5 before the Cardinal went on a 20-2 run to open a 20-point lead midway through the first half.
New Mexico kept the game relatively close for the first 7 minutes of the second half by dominating the offensive boards (20-12) and getting second chance points.
Owens and Brooke Allemand hit 3-pointers to cut Stanford's lead to 16, the closest the Lobos would get the rest of the way.
Looking ahead to Tennessee, Stanford owns consecutive wins over the Lady Vols and will be looking for a third straight for the first time in a series that dates to the early 1990s.