Griffin, who has been on a hot streak of late, finished with 20 points, seven rebounds and six assists.
Both of his parents attended the game.
With Russell Westbrook's return, decreased playing time was expected throughout the back end of the Thunder rotation.
Through two games, Jeremy Lamb looks like the one affected most.
Lamb only got 16 minutes and two shots on Sunday, his lowest shot total of the season and second-lowest minutes total since mid-December.
STATS OF THE DAY
*Kevin Durant has scored at least 40 points in 16 games the past two seasons. Sunday was only the third time the Thunder has lost.
*Despite the loss, the Thunder is still 15-2 against Western Conference teams at home this season.
The next week sets up as a nice get-well stretch for the Thunder. With days off in between, OKC's next four come against the Cavs, Grizzlies, Bobcats and Sixers, all at home. It starts with Cleveland at 7 p.m. Wednesday at Chesapeake Energy Arena.