Parsons opened the second half with a corner 3-pointer to pull the Rockets within nine points, but Durant hit two 3-pointers and Jackson had another during a 15-0 run to give Oklahoma City its biggest lead to that point at 71-47.
Houston came no closer than 17 points the rest of the way and Oklahoma City's lead eventually reached as many as 32 points, with Lamb putting on a shooting show, finishing 8 of 10 from the field, including 3 of 4 from 3-point range.
Houston had all five starters reach double figures in scoring in two of its previous three games, but only Parsons did so against Oklahoma City. Howard struggled against the defense of Oklahoma City's Kendrick Perkins and had nine points and nine rebounds.
Houston also struggled at the free throw line, hitting just 17 of 31 attempts (54.8 percent).
Sefolosha scored 13 points, one off his season high, for Oklahoma City. Omri Casspi added 15 points for the Rockets.