The story: Tennessee had won three straight national championships behind superstar Chamique Holdsclaw, who failed to secure a Final Four berth as a senior. Holdsclaw averaged 29 points through the Volunteers' first three tourney games, but hit just two of her 18 field-goal attempts and finished with eight points. She fouled out in the final seconds to end her stellar college career.
After the upset: Duke advanced to the championship game, losing to Purdue. Tennessee didn't win another national title until back-to-back championships in 2007 and 2008.
Quotable: “I think it's obvious we're in a lot of pain. Our seniors are champions. Three out of four is not bad.” — Tennessee coach Pat Summitt
2. (16) HARVARD 71, (1) STANFORD 67
Round: First round
When: March 14, 1998
Where: Palo Alto, Calif.
The story: Stanford entered the contest carrying a 59-game home winning streak, but lost two of its star players, Kristin Folkl and Vanessa Nygaard, to knee injuries just before the tournament. Harvard's Allison Feaster recorded 35 points and 13 rebounds in the victory, which remains the only 16-over-1 upset in NCAA Tournament history — men or women.
After the upset: Harvard lost in the second round, 82-64 to No. 9-seed Arkansas, and has made just three NCAA Tournament appearances since. The upset remains Harvard's lone tournament victory.
Quotable: “I can't tell you the amount of adversity we've faced, just coming in here. But somehow we did it. I am very, very happy. No one thought we could do it but us.” — Harvard coach Kathy Delaney-Smith
1. (5) LOUISVILLE 82, (1) BAYLOR 81
Round: Sweet 16
When: March 31, 2013
Where: Chesapeake Energy Arena
The story: Defending national champion Baylor entered having won 74 of its previous 75 games, and had arguably the greatest women's basketball player of all time, senior center Brittney Griner, on its squad. Louisville finished the regular season tied for third place in the Big East Conference standings. The Cardinals' 3-point shooting was dynamic and allowed them to open a 19-point second-half lead before Baylor made a fierce comeback. The upset was sealed — and Griner's amazing career ended.
After the upset: To be determined. Louisville plays Tennessee at 8 p.m. Tuesday in the regional final for a Final Four berth.
Quotable: “I told our kids in the locker room before the game, ‘We've got to turn this thing into a street ballgame. You got to drive, kick for threes, try to make it fun. There was no pressure on us.” — Louisville coach Jeff Walz