Devonta Abron led TCU (10-14, 1-10) with 12 points and Kyan Anderson scored 11 on 4-for-19 shooting.
The Horned Frogs missed their first 14 shots, including a pair of air balls, and didn't get on the scoreboard until Adrick McKinney hit one of two free throws with 11:52 left before halftime. Their first basket didn't go in until Connell Crossland scored inside with 8:49 left in the first half.
The Sooners scored the game's first eight points, led 15-1 midway through the first half and were up 36-11 at halftime after TCU missed 20 of its 24 field-goal attempts.
The Horned Frogs came in rated last in the conference in scoring, shooting percentage, rebounds, steals and blocks and played nowhere near the same level as during a stunning upset of then-No. 5 Kansas last week.
On Saturday, the Sooners got their own win against Kansas, their first upset of a top 5 team since 2006.
"We were just trying to step our defensive intensity up and just keep it going from the Kansas game and not have any letdown," Osby said. "They beat Kansas, they're a really good team and we just tried to take them out of their stuff."
Without Hield, fellow freshmen Isaiah Cousins and Je'lon Hornbeak could end up with more playing time. Cameron Clark, who started the past two seasons before moving to a reserve role this season, could also absorb some of Hield's minutes.
"Our depth is good," Kruger said. "You don't like to see injury, of course. It's an unfortunate part of the game. But having good depth helps when you do have injury or foul trouble or whatever."
Kruger has started two freshmen all season long, with Hield in the lineup for the past 13 games. Early on, Hornbeak and Cousins were starting together. Hield has been alongside one or the other since mid-December.
"Buddy is a terrific guy and we all love him to death. I think everybody around campus loved him to death. He was just doing such a great job of giving us energy that we're definitely going to miss it," M'Baye said. "Knowing Buddy, I know that from the court or from the bench he's still going to have the same production energy-wise to get us going."