Oklahoma scientists find way to slow cancer tumor growth in mice

Researchers at the Oklahoma Medical Research Foundation discovered a way to slow cancer tumors from growing in mice by removing a protein that regulates the formation of blood vessels. In some cases, cancer growth was stopped altogether.

 
By Jaclyn Cosgrove | Published: January 25, 2013    Comment on this article Leave a comment

photo - Scientists and researchers Yunzhou Dong, Hong Chen, Satish Pasula and Xiaofeng Cai made a recent discovery that could help improve cancer therapy. Photo by Jaclyn Cosgrove, The Oklahoman
Scientists and researchers Yunzhou Dong, Hong Chen, Satish Pasula and Xiaofeng Cai made a recent discovery that could help improve cancer therapy. Photo by Jaclyn Cosgrove, The Oklahoman

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“When we looked closer, we noticed that the blood vessels didn't function properly.”

The research was done using mice bred without epsins and also using human cells in a Petri dish.

The research is far from over, but it is a step that could lead to some interesting new therapies, Chen said.

For example, if doctors could slow or stop a cancer tumor from growing, it could mean more time to treat the patient. It could also mean less of a chance the tumor would continue to grow and damage the body.

“Obviously, we don't want cancers growing large, so we are trying to better understand the mechanics of angiogenesis — the creation of blood vessels — which led us to experiment with epsins,” Chen said in a news release.

The initial findings give a better understanding of the role epsins play. With a tumor, there's a higher density of epsins than in the rest of the body, Chen said.

The next step could be creating a drug that suppresses the creation of epsins.

Chen said it's a promising first step that could lead to better treatments and outcomes for cancer patients.

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