But two plays changed everything.
The Cowboy defense got back-to-back goal-line stops early in the second quarter and sparked OSU to a 48-14 win over the Jayhawks at Memorial Stadium.
â€œIt was a huge momentum swing for us,â€ defensive coordinator Bill Young said. â€œAny time you have a goal line stop like that, it's huge.â€
The Jayhawks offense looked nearly unstoppable early in the first half before OSU linebacker Orie Lemon stuffed two goal-line runs by Kansas turning the ball over to the Cowboys at the Jayhawk 1-yard line with 8:27 left in the second quarter.
â€œThe fourth down stop changed the tide,â€ defensive end Richetti Jones said.
Kansas had 252 total yards in the 21:33 minutes of play before the fourth-down stop and just 36 total yards in the final 38:27 minutes of play after the goal-line stop. KU finished with 288 total yards and had six drives of 10-yards or less.
After the stop, the Cowboys offense went on a 15-play, 96-yard drive, capped off by a 21-yard Dan Bailey field goal. OSU dominated from that point forward.
â€œIt got (the defense) off the field,â€ coach Mike Gundy said. â€œI think it settled down everybody.â€
After the stop, OSU outscored Kansas 31-0 en route to earning the program's first 10-win regular season.
Brandon Weeden passed for 389 yards and three touchdowns to lead OSU to at least a share of the Big 12 South title.
The Cowboys (10-1, 6-1 Big 12), can win the title outright if Baylor beats No. 16 Oklahoma later Saturday. The Sooners and Cowboys meet at Oklahoma State next Saturday.
Weeden set the school record for total offense and Kendall Hunter had 105 yards on 22 carries to close in on another Big 12 rushing title. Wide receiver Justin Blackmon extended his own Oklahoma State records with 100 yards receiving and a touchdown catch in his 10th straight game.
Kansas (3-8, 1-6) gave the Cowboys a surprisingly tough fight the first half, and even led 7-0 and 14-10 before Oklahoma State got it together.
Oklahoma State's Dan Bailey made field goals of 32 and 21 yards, but also missed two long ones, leaving him 22 for 26 for the year.
The Jayhawks had a drive kept alive by an unnecessary roughness call on Oklahoma State linebacker Justin Gent while trailing only 17-14. They drove to a first-and-goal from the 6 with about 6 minutes left in the first half.
But the Cowboys goal-line stops shifted the momentum.
The Cowboys went 96 yards in 15 plays before Weeden's pass on third-and-3 fell incomplete. Bailey's 21-yard field goal sent Oklahoma State into halftime with a tenuous 20-14 lead over the Jayhawks, who have won only two Big 12 games in two years.
Oklahoma State scored two touchdowns in the third quarter and Blackmon's 13-yard catch 9 seconds into the fourth put Oklahoma State on top 41-14. The nation's leader in yards receiving and touchdown catches finished with 130 yards on 10 receptions.
Weeden, who entered the game with 3,319 yards in total offense, surpassed the record of 3,671 Zac Robinson set in 2007. He was 31 for 43 and had a 21-yard TD pass to Josh Cooper that made it 17-14 early in the second quarter. His 3-yard scoring toss to Tracy Moore in the fourth that raised his season total to 30.
Joseph Randle's 14-yard run gave Oklahoma State its first touchdown. Jeremy Smith's 5-yard run made it 27-14 and then Michael Harrison blocked a punt and returned it 5 yards for a touchdown.
The Jayhawks scored a touchdown on their first possession for the first time this season. Chris Omigie got the 80-yard drive started with a 36-yard reception from Quinn Mecham and then Tim Biere capped it with a 12-yard touchdown catch.
The Cowboys took a 10-7 lead on Kendall Randall's 14-yard TD run and Bailey's 32-yard field goal.
But with 1 minute, 30 seconds left in the opening quarter, Kansas' James Sims got free down the left sideline and scampered 24 yards for another Kansas touchdown and a 14-10 lead. The drive was aided by a roughing-the-passer call on defensive end Ugo Chinasa.
The Cowboys hurt themselves all day with penalties. A personal foul on offensive lineman Lane Taylor pushed them to a third-and-16 from the Jayhawks 28, and then Blackmon's 26-yard catch-and-run to the 2 was wiped out by a holding penalty. Bailey, who had been 8 for 8 from the 40 and beyond, then missed a 46-yard attempt, keeping the lead 20-14. Bailey also missed from 50 yards.