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OMRF researchers target allergies

A process to mimic the immune system that was created by scientists at the Oklahoma Medical Research Foundation is being used to help combat allergies.
BY GREG ELWELL Published: June 12, 2012

Four years ago, Oklahoma Medical Research Foundation scientists created a revolutionary process that mimics the immune system. Since then, OMRF researchers have used the process to create illness-fighting proteins known as antibodies to help combat infectious diseases like influenza and anthrax.

With a new pilot grant, OMRF scientists are now aiming this technology at another target: allergies.

Allergies occur when the immune system overreacts to allergens like pollen, dust, pet dander and certain foods. The immune system creates antibodies that bind to the allergens and sweep them out of the system.

But a side effect of the reaction creates chemical mediators, such as histamine, which are released into the bloodstream, causing constricted airways, watery eyes, runny noses and more.

Using the technology developed at OMRF, scientist Ken Smith, Ph.D., will make antibodies to common allergy-causing substances in the lab. He will then map the location of the interaction that releases histamine and causes the physical symptoms of allergies.

“For years, we've been using this method to create antibodies to infectious diseases,” Smith said. “The antibodies can be useful for helping people with weakened immune systems or to provide immunity for people going into pandemic-type situations.”

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