The Texas game is sandwiched by two bye weeks. After the second open date, OSU will face Kansas in Lawrence on Oct. 13 before an intriguing Homecoming date with Iowa State, the only team to beat the Cowboys in 2011.
OSU opens the season on Sept. 1 against Savannah State, a Football Championship Subdivision team that went 1-10 last season.
The Cowboys will then see two familiar nonconference foes the next two weeks, facing both Arizona (Sept. 8) and Louisiana-Lafayette (Sept. 15) for the third time in as many seasons.
OSU beat Arizona 36-10 in the 2010 Almo Bowl and 37-14 last season in Stillwater. But a new coaching staff will be in place when the Cowboys make the return trip to Tucson, as offensive guru Rich Rodriguez was hired to replace Mike Stoops, who was fired midseason.
The Cowboys routed Louisiana-Lafayette 54-28 on the road in 2010 and 61-34 at Boone Pickens Stadium last season.