The Sooners couldn't throw it, but West Virginia couldn't stop Clay and Williams on the ground.
After Clay's back-to-back big runs, the Sooners tried to pass and Trevor Knight was picked off.
Clay began the next Oklahoma drive with a 32-yard gain.
His 170 yards on 22 carries were the most by an OU player since DeMarco Murray rushed for 208 against Utah State in 2010.
It was a career-high rushing mark and just the second 100-yard game of his career.
Clay, Williams and Stoops all credited fullbacks Millard and Aaron Ripkowski for a big part of the way OU was able to gash through the Mountaineers' defense.
“I think our lineman blocked really well,” Stoops said. “They were bringing a lot of blitzes, a lot of stunting with our offensive line and Aaron Ripkowski and Trey Millard picked that up.
“Sometimes you blitz yourself right out of the play. When it's blocked correctly, you have a chance to hit them and we did tonight.”
This might be how the Sooners have to win this year — on the backs of Clay and Williams.
“That's hard on a defense,” Clay said. “You can get discouraged by that when we're breaking off 20-30 yards over and over.”