Granger started 11 games a year ago and was named second team All-Big 12.
"That first half (at Washington) was like, ‘That's the guy,' ” said OU defensive coordinator Brent Venables. "He was playing really well.
"We'll miss his presence.”
Junior Cordero Moore moves into the mix to add depth, but Venables said the other three tackles — Gerald McCoy, Cory Bennett and Taylor — would likely inherit a good share of the additional reps.
Defensive line coach Jackie Shipp said that the plan remains to redshirt freshmen tackles Stacy McGee and Casey Walker.
"It impacts us, but we have to move on,” McCoy said. "I'm not saying we're not going to miss Granger being out there, but we're a whole defense. If one of our brothers goes down, we've got to keep pushing. Even a person that important to us, we've got to keep on pushing.
"I'm going to miss him out there, because Granger is my partner.”