Wilson, 20, of Carrollton, Texas, was driving a sports utility vehicle southbound at the 81-mile marker near Pauls Valley about 1 p.m. when, for an unknown reason, his vehicle collided with a pickup driven by Kody R. Thomas, 20, of Broken Arrow, which was also traveling southbound.
Both vehicles left the roadway and rolled.
Wilson was thrown about 45 feet from his SUV and was flown with head and internal injuries to OU Medical Center. Thomas refused treatment at the scene.
Wilson was not wearing a seatbelt, troopers said. Thomas was wearing a seatbelt.
A hospital spokesman said Wilson's family has asked that his condition not be released.
Wilson, who was a redshirt freshman this past season, is the younger brother of former OU standout wide receiver Travis Wilson.