The Sooners turned the ball over four times in the final 11 minutes, They failed to force a turnover on the other end.
In Baylor's first season of the post-Brittney Griner era, senior guard Odyssey Sims is on pace to break the league's scoring record set by Oklahoma State's Andrea Riley with 26.7 points per game in 2010.
Sims had 27 points, dropping her season average to 30 points per game.
“It would be hard for me to believe there's a guard in the country that gets guarded like she does night-in and night-out,” Mulkey said. “She just has really kept her composure being guarded the way she has been guarded.”
Freshman Nina Davis scored 19 points and had 14 rebounds for the Bears (19-3, 9-1) while another freshman, Imani Wright, added 15 points.
Hook led the Sooners with 18 points. Freshman Gioya Carter equaled her season high with 12 points.
After the disastrous first half on the boards, the Sooners equaled Baylor's rebounding numbers after halftime.
“I'm proud of the ones that came in and stepped up,” Hook said. “When our two best scorers went out of the game, we didn't cower down and lose by 40. We came back and kept fighting.”