Missouri won six of the 10 matches in its biggest dual win of the season.
“I'm excited with that result because we're really young,” said Missouri coach Brian Smith. “They're starting five seniors and we're starting five freshman, so to come down here and get a win is great.”
The bright spots for OU came from Cody Brewer at 133 pounds and Andrew Howe at 184 pounds.
Eighth-ranked Brewer gave the Sooners their first lead in the dual's second match with an 18-3 technical fall over Perry native Matt Manley.
Howe, ranked No. 1 at 174 pounds, had OU's other bonus-point win as he bumped up a weight and picked up a 22-9 major decision over Cody Johnston.
Missouri now heads to Stillwater where it will take on No. 9 Oklahoma State at 7 p.m. on Friday.
OU's next action will be at West Virginia for a 6 p.m. dual next Thursday.