Gerald Henderson led the Bobcats with 15 points, while Kemba Walker and Ramon Sessions each had 13.
As has often been the case this season, the Bobcats got off to a slow start, falling behind 20-9 early.
The Pacers, led by Hibbert and West, dominated the paint from the outset, outscoring the Bobcats 18-2 in the first quarter.
With Byron Mullens still out with a lingering ankle injury, the Bobcats started Bismack Biyombo at center and Hakim Warrick at power forward. They combined for just seven rebounds in 37 minutes of action.
"I don't remember us having a game like that where we got outrebounded that bad," Bobcats guard Ben Gordon said. "I think there are a lot of times where we put teams on their heels when we have those guards out there. We just need to continue to use that to our strength, but tonight I just think it was more of a lack of energy, lack of effort type of thing."
After the game, coach Mike Dunlap refused to say if the Bobcats need to add some big men next offseason, saying "I prefer to stay in my lane" and allow the personnel decision-makers to make that call.
As for Jordan, he made a quick exit early in the fourth after the Pacers pushed the lead to 30.
Playing their fourth game in five nights, the Bobcats shot just 34 percent from the field and played without much emotion or enthusiasm.
The Pacers seemed to take advantage of that lack of energy early and the game en route to starting another winning streak.
"We take pride in bouncing back from a loss and not losing two in a row," said Indiana's Tyler Hansbrough.
NOTES: North Carolina coach Roy Williams had courtside seats to watch Hansbrough. ... Walker left in the second quarter after tweaking his ankle but returned in the third. ... The Bobcats have failed to score more than 90 points in each of their last four games. ... George has a double-double in each of his last four games.