"Last night, we were able to come back by making shots down the stretch," Collins said. "Tonight, they were the ones who made the big baskets. They just hit big shots tonight."
Nick Young scored 13 points for the 76ers. Evan Turner added 12 while Thaddeus Young had 11.
Pargo's previous career high came last season against Oklahoma City when he scored 15 points. He made five starts as a rookie with Memphis in 2011-2012, but — totaling 23 minutes. Cleveland acquired him in an offseason trade.
Cleveland led 65-50 midway through the third quarter, but the 76ers chipped away at the margin. Nick Young's basket with 3:31 to play cut the lead to 79-77, but Cleveland put the game away with a 13-0 run. Two free throws from Varejao and 3-pointers by C.J. Miles and Waiters rebuilt the lead.
Irving has had several injury setbacks. He has missed time with a foot injury, sprained shoulder, concussion and broken hand in the past two years. The Cavaliers went 4-11 without Irving in 2011-12. Irving, looking sharp in a suit and tie, was seated at the end of the bench.
Daniel Gibson, Cleveland's backup shooting guard, missed his second straight game with a sore right elbow.
Notes: Philadelphia was 4 of 26 from the field midway through the second quarter. ... The Cavaliers had lost six straight to the 76ers. Their last victory in the series was a 101-93 win in Cleveland on Nov. 16, 2010. ... The 76ers host Oklahoma City on Saturday, the first of three straight games at home. ... Cleveland begins a three-game road trip Friday in Orlando. The Cavaliers also play in Miami and Memphis. ... Former Cavaliers F Larry Nance, the NBA's first slam dunk champion, attended the game.