Little was left standing alone in front, where he was set up by Evander Kane, who outmuscled two Sabres defenders to dig out the puck at the end boards.
Nathan Gerbe's giveaway inside his own zone led to Ladd's goal 6 minutes into the second period.
"Something needs to get shaken up with our attitude more than anything," Miller said. "It's definitely mental on our part."
Miller was otherwise sharp in finishing with 26 saves, and bailing out his teammates on several defensive miscues. Miller foiled Jim Slater trying to beat him through the legs on a breakaway with 2 minutes left in the opening period. He also made a diving poke check to stop Kane on a partial short-handed breakaway with 20 seconds left in the first period.
Pavelec, appearing in his 200th career NHL game, was equally sharp for the Jets.
His best save came with just more than 5 minutes left when he kicked out his left pad just in time to stop T.J. Brennan's hard shot from the left circle. Then there was his left pad save in stopping Tyler Ennis from in close with 1:14 remaining.
Pavelec also made a sharp glove save to stop Drew Stafford set up alone in the lower left circle with 1:44 left in the first period.
"Every save is important," Pavelec said. "It was nice to see we had the lead in the third, and it was nice to see we closed the game and get the two points."
NOTES: Sabres D Jordan Leopold became the latest to land in coach Lindy Ruff's doghouse, becoming a healthy scratch for the first time this season. ... Jets penalty killers went 3 for 3 after entering the game having allowed an NHL-worst 15 goals on 44 power-play chances. The Jets are 4-0-1 when they don't give up a power-play goal. ... Pominville's goal snapped a six-game point drought that matched the longest of his career, according to STATS. ... The Jets have not lost four in a row in regulation since a four-game skid from Jan. 21-31, 2009, when they were the Atlanta Thrashers.