Washington made one in the first quarter. Kevin Seraphin was alone by the basket, and instead of an easy layup, he tried a reverse dunk — and the ball spun out.
Washington shot just 17.4 percent (4 for 23) in the first quarter and trailed 22-13. Detroit shot 36 percent.
"The last two games were embarrassing. There's no word better than that," Nene said.
With the Wizards off for the next three days, Wittman started Nene for the first time this season. Nene has missed 12 of Washington's 25 games with a left foot injury.
The Wizards' Cartier Martin helped cut the lead to seven, but a few moments later, Detroit hit three straight 3-pointers for a 39-22 lead and the Pistons led at halftime 54-35.
In the second half, Detroit built its largest lead, 59-37 a little more than two minutes into the third quarter, but Tayshaun Prince sprained his right ankle in a collision, left the game and did not return.
"We'll know more in the next couple of days but right now I think we're labeling it as a sprain," Frank said.
Washington ran off 10 straight to get within 59-47 with 7:08 to play, got within six with just about four minutes remaining in the quarter and trailed 74-64 after three.
Villanueva had seven points in the first few minutes of the fourth quarter as the Pistons held off Washington.
"Playing a team back to back is very difficult, especially the way we won (Friday) night," Villanueva said. "We knew they were going to come out and give us all they had. Give them credit, they made their run, but we stayed poised and made the plays and got the stops that we needed."
Notes: Pistons rookie F Andre Drummond had 25 rebounds in the two games against Washington. ... Detroit F Corey Maggette was inactive for the second straight game. ... Washington G John Wall, who's missed all season with an injured left knee, has started running on the court, Wittman said. ... Wizards G Bradley Beal, who missed the previous two games with an injured back, returned and scored 14 points.