McFadden ran for 17 yards on seven carries. He was stopped for no gain on his final try, and it was not certain how he was hurt.
Drafted fourth overall in 2008, McFadden has excelled when he's been healthy. But he missed 19 games in his first four seasons with foot, toe, shoulder, knee and hamstring injuries.
Raiders backup running back Mike Goodson limped away after injuring his right ankle in the fourth quarter. Safety Matt Giordano hurt his hamstring when he missed a tackle on Doug Martin's 67-yard touchdown run.
Seattle linebacker K.J. Wright left in the first quarter of the Seahawks' 30-20 win over the Vikings with a concussion and did not return.