CINCINNATI (AP) — For the first time in four years, the Reds let an eight-run lead slip away.
Mat Latos struggled in his second start since coming off the disabled list, and Cincinnati's bullpen couldn't hold on at the end, allowing Toronto to rally for a 14-9 victory on Friday night.
Edwin Encarnacion hit a three-run homer to start the second-biggest comeback in Toronto's history, then completed it with another three-run shot as the Blue Jays pulled away with five runs in the ninth inning.
The Reds' pitching meltdown wasted a chance to get back to .500 for the fourth time this season. Cincinnati has yet to have a winning record.
It was the first time the Reds blew an eight-run lead and lost since May 20, 2010, at Atlanta, a 10-9 defeat. The Reds gave up a season-high nine walks.
"I don't know what it is," manager Bryan Price said. "Fortunately, it's only one loss. It's an ugly type of loss. It's the type of loss that affects everybody."
Toronto hit four homers during its comeback, including the two by the major leagues' home run leader.
The Reds scored eight times in the second, their biggest inning of the season.
Encarnacion started the comeback by connecting in the third inning off Mat Latos and finished it with his 23rd homer off Sam LeCure during the five-run ninth inning.
"After the (first) three-run homer, we got the emotion back," said Encarnacion, who set a career high with his six RBIs. "We were feeling like we could come back after that."
Brett Lawrie and Juan Francisco also homered for Toronto.
Toronto overcame a 10-run deficit to beat Boston 13-11 in 12 innings in 1989.
With the score tied at 9, Aroldis Chapman (0-2) came on to pitch the ninth and walked leadoff hitter Colby Rasmus. Erik Kratz doubled off the wall in left field to break the tie, and then came around on Melky Cabrera's single.
Chapman was replaced after getting only two outs. Encarnacion completed the big comeback and his sixth multihomer game of the season.
Dustin McGowan (4-2) pitched a perfect eighth. Casey Janssen retired the three batters he faced in the ninth for his 13th save in 15 chances.