"We know he's a great dual-threat quarterback, but once we bottle it up and frustrate him, we know he's going to tank a little bit," Seahawks safety Earl Thomas said of Newton. "We were able to do that today."
Carolina started the season with plenty of optimism with the return of Newton to lead a high-scoring offense, but the Panthers couldn't rebound a week after losing 30-28 to the Falcons on Matt Bryant's field goal with 5 seconds left.
"This is by no stretch done," second-year Panthers coach Ron Rivera said. "This is 1-4 and we're not going to quit. We're going to show up and we're going to be back on the job (Monday). We will find answers and we're going to win."
The game marked a homecoming of sorts for Wilson, who first gained acclaim as a quarterback at North Carolina State. He also played minor league baseball in Asheville and Gastonia before returning to college football and finishing up at Wisconsin.
The rookie hadn't thrown for more than 160 yards in a game until Sunday, but didn't panic when he threw the two interceptions and bought time with his mobility on several plays.
"I felt like we had so much control there," Wilson said. "I made sure everyone was on the same page, and even changed the snap count a lot. We did a lot of great things today. ... Obviously, some of the penalties pulled us back, as did the turnovers, but we still did a lot of great things."
Notes: The Panthers played without three starters; cornerback Chris Gamble, linebacker Jon Beason and offensive lineman due to injuries. ... Newton targeted receiver Steve Smith a season-high 13 times. The previous high was 11 in the opener at Tampa Bay. ... Seattle tight end Zach Miller had three catches for a season-high 59 yards, including a season-long 30-yard catch. ... Rice had five catches for 67 yards. ... Williams and Jonathan Stewart combined to rush for 22 yards for Carolina. ... Steven Hauschka kicked three field goals for Seattle.