In 2010, the solar plane flew non-stop for 26 hours to demonstrate that the aircraft could soak up enough sunlight to keep it airborne through the night. A year later, it went on its first international flight to Belgium and France.
Last year, the Solar Impulse made its first transcontinental voyage, traveling 1,550 miles from Madrid to the Moroccan capital Rabat in 20 hours.
Before its coast-to-coast American trip, the Solar Impulse will take test flights around the San Francisco Bay Area in April, officials said.
Piccard and Borschberg are planning an around-the-world flight in an improved version of the plane in 2015.
Piccard comes from a line of adventurers. His late father, Jacques, was an oceanographer and engineer who plunged deeper into the ocean than any other person. His grandfather Auguste, also an engineer, was the first man to take a balloon into the stratosphere.
Bertrand Piccard and Brian Jones made history in 1999 when they became the first people to circle the globe in a hot air balloon, flying 25,000 miles nonstop for 20 days.