Defenses will have less time to adjust to OU's offense, which can run anything from three tight ends to five wideouts using almost the same players in either.
That could create significant mismatches such as isolating Murray on a linebacker in the slot.
On top of that, OU should get more snaps from scrimmage, prompting quarterbacks coach Josh Heupel to compare it to Billy Tubbs' style of coaching basketball.
"It gives you more opportunities. It's like fast-break basketball. Up and down,” Heupel said. "You know, ‘Billy Ball.' Get as many shots as you can.”
The defense could also prosper from practicing how to adjust to the no-huddle everyday in practice for when they see it on Saturdays.
"There's some nuisances that help you deal with it, practice at it,” defensive coordinator Brent Venables said. "There's a lot of intricacies to how you prepare for it.”
OU also has the mastermind to implement the no-huddle.
Wilson has plenty of knowledge in calling plays out of a no-huddle offense dating back to his days as offensive coordinator at Northwestern and Miami (Ohio), which both ran versions of it.
"The defensive coaches thought it would be good,” Wilson said. "Going no-huddle is nice, but you better be able to block and take care of the ball.
"We won't go to it if we don't think it's going to be a good thing.”