Spain opened the defense of its World Cup title with a 1-0 win at Georgia on Roberto Soldado's 86th-minute goal Tuesday night, while England stumbled to a 1-1 tie at home against Ukraine.
Spain, the world and European champion, has won 23 consecutive qualifiers since 2007. Soldado scored off a cross from Cesc Fabregas, who entered six minutes earlier.
"It was a hard-fought win against a rival that gave us the ball but pulled back into its area," Soldado said, who was given a rare start up front ahead of Fernando Torres and the fit-again David Villa. "It was bewildering."
Italy, Germany and Portugal all failed to impress despite victories on the second day of European qualifying for the 2014 tournament in Brazil.
The United States (2-1-1) moved back into a tie for its group lead in the North and Central American and Caribbean semifinals, winning 1-0 at home against Jamaica as Herculez Gomez curled in a free kick in the 55th minute.
Mexico (4-0) became the first nation to advance to next year's six-team CONCACAF finals, winning 1-0 at home against Costa Rica on a 61st-minute goal by Javier Hernandez.
South American leader Argentina (4-1-2) rallied for a 1-1 tie at Peru, with Gonzalo Higuain scoring in the 36th minute, 15 minutes after Carlos Zambrano had put the hosts ahead. Colombia (4-2-1) won 3-1 at Chile, Uruguay came from behind to tie Ecuador 1-1 on a 61st-minute goal by Edison Cavani, and Venezuela won 2-0 at Paraguay on a pair of goals by Salomon Rondon.
At Wembley, Frank Lampard converted a penalty kick in the 87th minute after Yevhen Khacheridi was called for a hand ball. Yevhen Konoplianka scored for Ukraine in the 39th minute, crisply curling the ball from 25 yards into the top corner of Joe Hart's goal.
Already missing Wayne Rooney, John Terry and Ashley Cole because of injuries, England finished a man short after Steven Gerrard was ejected in the 88th for his second yellow card.
"These games are not easy and in the end getting a point is a good result considering we were 1-0 down with 10 minutes to go," Lampard said.