"It's only one game. It doesn't mean anything," Parker said. "You have to look at the big picture. We want to win a championship."
San Antonio put on a free-throw shooting clinic in the third quarter, making 16 of 20, including 12 during a 14-4 run that extended its lead to 81-53.
Popovich said he tried to call a couple plays, but Parker overrode him.
"He's really matured as a player," Popovich said. "He just used to be a scoring point guard. Now there's a whole new world out there. He's a complete player."
Parker said, "He's always trusting me and letting me grow as a point guard and calling plays. Before in my career I was always looking at him. Now I don't look at him."
The Spurs shot 63 percent to lead 58-43 at halftime. Parker scored 17 points in the half, while Griffin was the only Clipper in double figures with 13 points. Paul didn't make his first basket until the final 3 minutes of the second quarter.
San Antonio made its first six shots to start the game and used a 17-4 run, including seven by Manu Ginobili, to close out the first quarter leading 34-21.
NOTES: San Antonio improved to 6-1 on its nine-game rodeo trip. ... The Clippers dropped to 21-6 at home. ... Spurs F-G Stephen Jackson played for the first time since his wife had a miscarriage. He had left the team in Chicago on Feb. 11. ... Spurs F Kawhi Leonard was held out for precautionary reasons because of soreness in his left knee, the same reason he missed 16 games earlier in the season. ... Adam Silver, who will succeed David Stern as NBA commish, attended the game. ... There was a moment of silence for late Lakers owner Jerry Buss, who died Monday.