Parker had three of the team's seven assists in the first quarter.
Parker sat for 9 minutes in the second period after playing the entire first. With the All-Star point guard on the bench, Jackson and Neal combined for nine points in an 11-0 run that gave the Spurs a 37-18 lead to open the second.
Indiana did not surpass 20 points until West dunked off an offensive rebound with 7 minutes left in the first half.
West kept the Pacers in contention, scoring all 10 of his points in the second quarter while going 4 for 5 from the field. His 23-foot jumper cut San Antonio's lead to 47-38 at halftime.
The Spurs never trailed by fewer than 10 points in the second half.
The Pacers shot just 35 percent from the field in the game. San Antonio forced 14 turnovers in the second half.
"Their continuity is evident just watching them play," Indiana coach Frank Vogel said. "Thirteen of their 14 guys were here last year and their core guys have been here for many years winning championships. It's a system they are familiar with. They are a well-oiled machine and they play extremely hard on both sides of the court."
NOTES: Indiana forward Danny Granger missed his fourth game with a sore left knee. Granger is out indefinitely. ... Former Indiana Pacers point guard Haywoode Workman was among the game officials. Workman played for the Pacers from 1993-99 and spent parts of four other seasons with three other clubs. His final season in the NBA was 2000 with the Toronto Raptors. ... Hill received a loud ovation during pregame introductions. ... Parker went flying over the first row of courtside seats while chasing down a loose ball in the second half. He landed partially on Ed Whitacre, bending the eyeglass frame of the former CEO of General Motors and AT&T.