"Harbaugh makes the move to a second year quarterback with no road experience and they just keep winning," added Pat Kirwan of SiriusXM NFL Radio/CBSSports.com. "Aldon Smith looks unblockable coming off the edge."
Denver was fifth, followed by Baltimore the New York Giants, Chicago, Indianapolis and Green Bay, which fell four spots after its 38-10 loss to the Giants.
"When they click, no team is better, as the Packers and 49ers could attest," Dan Pompei of the Chicago Tribune said of the Giants.
As for the surprising Colts (7-4), Clark Judge of CBSSports.com said, "This is better than a feel-good story. This is a pretty good football team."
Cincinnati was the biggest gainer — up six spots to 11th after another convincing win, this time 34-10 over Oakland. The Colts moved up five spots after beating Buffalo 20-13 for their highest ranking of the season after starting out 32nd and last.
The Philadelphia Eagles continued their slide, dropping three more spots to 29th after their seventh loss in a row. The Eagles opened the season ranked eighth.
Kansas City (1-10) was a near unanimous choice for 32nd and last.
"A strong showing against Peyton Manning and the Broncos gets the Chiefs out of the cellar this week," said John Lynch of Fox Sports.
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Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL