Here's a look at how our coverage crew, and a couple others, picked Saturday's game:
JENNI CARLSON, Columnist
* Oklahoma 42, Missouri 20: The Tigers aren't going to sneak up on the Sooners this year. This OU squad is more mature and more talented than it was last season. Oh, and the Sooner just don't lose at home.
BERRY TRAMEL, Columnist
* Oklahoma 42, Missoui 21: Sooners generally pulverize good opponents on Owen Field.
TRAVIS HANEY, OU writer
* Oklahoma 44, Missouri 20: Missouri had lost seven straight to Oklahoma until last year. The Sooners haven't lost at home to the Tigers since 1966. That's not a fluke. Mizzou had put up some gaudy numbers on the ground, but playing a weak Western Illinois team helped. MU will struggle to stop Ryan Broyles and Landry Jones through the air. This one's easy for the Sooners, who again click offensively.
MIKE BALDWIN, OU writer
* Oklahoma 34, Missouri 17: The Sooners win at home (37 in a row). They usually win big. But this is a good test. The Tigers won last year in Columbia. Mizzou has a ton of starters back. The key matchup is MU's ground game versus OU's front seven.