Oklahoma City took control early in the second quarter with an 11-0 run that included Durant's 3 and his two-handed dunk on a drive down the left side of the lane. The surge made it 41-23, and the Hornets never got closer than 10 points again.
Anderson, among the NBA leaders in made 3s coming in, struggled to find his range, missing his first six from deep before finally hitting his seventh to pull New Orleans to 54-44 at halftime.
Durant then opened the second half with his second 3 and Westbrook continued to dominate, tossing up an alley-oop lob to Durant in between his own jumper and mid-range fade.
"Russell was Russell. He was able to get me open shots and I just tried to do my part," Durant said. "He sets the tone for us by pressuring the point and disrupted them early on."
Westbrook capped his night in the final moments of the third quarter by converting a fast-break layup and draining a 27-footer at the horn to give Oklahoma City a whopping 84-57 lead heading into the final period.
That allowed Brooks to empty his bench and give his stars a well-deserved rest in what served as a dominant encore to a 12-point victory over Utah a night earlier.
For Westbrook, it was a sign of increased maturity for the Thunder, who have been able to avoid falling into the trap of playing down to the level of struggling opponents.
"As a team we're doing a better job of not focusing on who we're playing, but focusing on ourselves and trying to find a way where we can get better," Westbrook said.
Notes: The Hornets lost the teams' first meeting this season 110-95 in New Orleans on Nov. 16. The teams will meet twice more in Oklahoma City on Dec. 12 and Feb. 27. ... The crowd included actors Steve Zahn and Wendell Pierce, stars of the New Orleans-based HBO series "Treme." ... Oklahoma City improved to 5-0 in the second of back-to-back games this season. ... Hornets reserve PG Brian Roberts played despite feeling ill earlier in the day, finishing with eight points on 3-of-5 shooting to go with an assist and a rebound.