Tori Jankoska added 19 points, Anna Morrissey 11 and Jasmine Hines 10 for the Spartans (3-1). Powers is the first player in the MSU women's basketball program to open the season with four straight double-doubles.
Olivia Nash led the Golden Grizzlies (1-3) with 17 points and seven rebounds. Elena Popkey added 14 points and Nola Anderson 12.
Michigan State made 18 of 38 shots for 47.4 percent in taking a 41-27 halftime lead over Oakland. Powers had 16 points and seven rebounds. The Golden Grizzlies shot just 30 percent in opening half.
Michigan State led by as many as 20 points in the second half.
The Spartans dominated the boards, 52-25, including 14 offensive rebounds as they scored 42 points in the paint to Oakland's 26.
No. 22 GEORGIA 66, COLGATE 35
ATHENS, Ga. (AP) — Shacobia Barbee scored 16 points and dished out five assists to lead No. 22 Georgia to a rout of Colgate.
Georgia led 19-17 with 6:54 remaining in the first half, then forced eight turnovers during a 13-2 run to build a 32-19 halftime lead. The Bulldogs (6-0) led by double digits the rest of the way, and finished with 16 steals.
Barbee was 7 of 13 from the field, and was one assist shy of her career best. Merritt Hempe added 10 points for the Bulldogs.
Colgate's Carole Harris hit the first bucket after the break. The Bulldogs answered with an 11-0 run to lead 43-21 with 13:49 to play.
Harris scored 14 points on 6-of-13 shooting to lead Colgate (0-4), which shot just 13 of 42 for 31 percent from the field.
No. 22 WEST VIRGINIA 83, EVANSVILLE 39
MORGANTOWN, W.Va. (AP) — Bria Holmes scored 32 points to lead West Virginia over Evansville 83-39.
The Mountaineers (3-1) scored the first seven points of the game and raced out to a 16-3 lead before Evansville could settle in as the Purple Aces (1-3) missed 9 of their first 10 shots. Sara Dickey's layup with 5:14 in the half cut the deficit to seven, but West Virginia used a 15-3 run to close the half and lead 41-22 at the break.
West Virginia pounded the ball inside after the break — its first six field goals were all layups — with Averee Fields and Holmes taking advantage underneath. Fields finished with 12 points on 5-of-9 shooting. Teana Muldrow had nine points and nine rebounds for WVU, which out-rebounded Evansville 62-31.
Dickey paced Evansville with 16 points, but was just 4 of 21 from the floor.