Azura Stevens led Duke (13-6, 4-2) with 24 points and nine rebounds. Elizabeth Williams had 19 points and nine boards, and Rebecca Greenwell added 11 points.
Stevens cut Duke's deficit to two points with four seconds left, but Hughes sealed the win with two free throws.
Duke entered the game averaging 75 points per game, but was held to 18-of-55 shooting (32.7 percent).
No. 16 NEBRASKA 89, WISCONSIN 72
MADISON, Wis. (AP) — Tear'a Laudermill and Emily Cady combined for 34 of their 43 points in the first half on to lead Nebraska to a win over Wisconsin.
Laudermill had 18 of her 24 points and Cady 16 of her 19 as the Cornhuskers (15-3, 5-2 Big Ten) shot 62 percent in the first half for a 53-31 lead.
Rachel Theriot added 11 points, Hailie Sample 10 and Cady, who hit 8 of 9 shots, grabbed 12 rebounds as Nebraska won its fifth straight.
Dakota Whyte and Nicole Bauman had 15 points each for the Badgers (7-11, 3-5). Tessa Cichy scored 14 and Cassie Rochel 10 with 12 rebounds.
Wisconsin only trailed by seven with 8:17 to go in the first half when the Huskies went on a 14-2 run to lead 39-20 on a Theriot jumper at the 4:15 mark. The Badgers never got closer than 14 early in the second half.
No. 18 MISSISSIPPI STATE 64, MISSISSIPPI 62
OXFORD, Miss. (AP) — Morgan William drained a step-back jumper with four seconds to play to snap a tie and give Mississippi State the edge it needed to beat Ole Miss.
William made back-to-back layups with 4:58 left for a six-point lead, but the Bulldogs did not score another field goal until William's game-winner. Ole Miss slowly chipped away at the difference, and Shequila Joseph split a pair of free throws to tie it at 60-all with one minute remaining. Two free throws from Victoria Vivians and a Danielle McCray basket kept the score tied with 14 seconds left.
William finished with 14 points on 5-of-7 shooting. Breanna Richardson scored 16, Martha Alwal had 14 and Vivians chipped in 10 for the Bulldogs (20-2, 5-2 SEC).
A'Queen Hayes led the Rebels (14-6, 4-3) with 12 points, and Tia Faleru added 11 rebounds.
No. 20 IOWA 76, MICHIGAN 70
IOWA CITY, Iowa (AP) — Melissa Dixon scored 12 of her 16 points in the second half and all five starters scored in double figures on Thursday in Iowa's win over Michigan.
Samantha Logic had 13 points, 11 assists and 7 rebounds for the Hawkeyes (15-3, 6-1 Big Ten), who won their fourth straight and improved to 11-0 at home. Ally Disterhoft added 14 points, Bethany Doolittle 13 and Whitney Jennings 12.
Cyesha Goree had 26 points and 13 rebounds for the Wolverines (12-6, 4-3) and Katelynn Flaherty had 19 points off the bench.
Iowa scored on its first five possessions of the second half for a 46-34 lead. Michigan trailed by 14 but cut the deficit to five on two Goree free throws with 1:46 to go and four on a Siera Thompson 3 with nine seconds left before Doolittle iced it.
Michigan, fifth in the nation shooting 3s at 39.8 percent, was 0-8 in the first half and 5-21 for the game.
PURDUE 90, No. 21 MINNESOTA 88
MINNEAPOLIS (AP) — Whitney Bays scored 25 points, including the game-winning jumper with 3.4 seconds left in overtime, to give the Purdue women an upset over Minnesota.
Bays also tied the game at 88 on a jumper with 1:08 left and finished with six of Purdue's 13 points in an overtime period that had four ties and four lead changes.
The Boilermakers (10-9, 3-5 Big Ten) led 79-75 with 1:54 left in regulation, but Shae Kelley had a free throw and a three-point play for Minnesota (16-3, 5-2) to force the extra period.
Liza Clemons and Ashley Morrissette both scored 19 and April Wilson added 17 points for Purdue. Wilson also handed out 12 assists and Clemons grabbed 10 rebounds.
Amanda Zahui B. led Minnesota with 26 points and Kelley added 20 with 12 boards. Shayne Mullaney had a career-high 15 assists to go with 11 points.
No. 23 SYRACUSE 68, PITTSBURGH 60
PITTSBURGH (AP) — Alexis Peterson and Brianna Butler scored 14 points apiece and Syracuse beat Pittsburgh.
Pitt's Yacine Diop made back-to-back buckets to bring the Panthers within two at 62-60 with 3:31 left. But Syracuse ran off six straight points — including a jumper and free throw from Diamond Henderson — and Pitt didn't score again, missing its last six shots and two free throws.
Syracuse (14-5, 4-2 ACC) raced out to a 10-4 lead in the first five minutes, backed by an Isabella Slim 3-pointer. A 6-0 run late in the half gave the Orange a four-point lead, 30-26, at the intermission.
Cornelia Fondren scored 13 points with 10 boards while Briana Day had 11 points and 10 rebounds for the Orange.
Pittsburgh (12-6, 2-3) was led by Monica Wignot with 16 points. Brianna Kiesel added 14 points and Stasha Carey had 11 points and 12 boards.
No. 24 WESTERN KENTUCKY 80, UTEP 74
BOWLING GREEN, Ky. (AP) — Chastity Gooch scored 19 points, grabbed seven rebounds and had eight steals to help Western Kentucky beat UTEP to stretch its winning streak to 14 games.
Micah Jones had a game-high 22 points, going 10 of 12 from the free throw line, for Western Kentucky (17-2, 6-0 Conference USA). Tashia Brown was 5 of 8 from the field and hit all six of her free throws for 17 points. Alexis Govan hit 4 of 4 free throws and finished with 10 points as the Lady Toppers converted 30 of 36 from the line.
Cameasha Turner led UTEP (8-7, 3-3) with 18 points. Lulu McKinney had 16 and Anete Kirsteine 15. The Miners were hurt by 24 turnovers.
Lawna Kennedy pulled UTEP within 70-66 with 56 seconds left, but Jones, Govan, Kendall Noble and Ivy Brown combined to hit 10 of 10 free throws to seal it.