Townsend rolled out and found Molinsky in the back of the end zone in heavy traffic.
Santa Fe, already hurt by key injuries, suffered another blow when running back Ryan Frazier injured his knee in the third quarter.
The Wolves never packed it in, however. A 41-yard punt return by Reece set up Santa Fe at the Edmond North 39-yard line with under a minute left before the Wolves turned the ball over on downs.
The Edmond North defense caused two turnovers in the second half and converted those into 10 points.
"Our defense came up huge," Townsend said. "They gave up 10 points, but we put them in a bad spot."
Townsend threw for 231 yards and two touchdowns. The rush defense was stout for both teams. The Huskies (4-5, 3-3) only had 33 yards on the ground. Santa Fe finished with 30 rushing yards.