The Indians chased Deduno and added three runs in the seventh on Drew Stubbs' RBI single and Kipnis' floater that found a place to land in left.
Mark Reynolds singled and Deduno walked Lonnie Chisenhall before he was replaced by Josh Roenicke, who got one out but gave up Stubbs' run-scoring hit. Brian Duensing came on and got one out and walked Mike Aviles to load the bases before Kipnis dropped a soft single over shortstop Jamey Carroll's head to make it 5-1.
"I'm not happy we lost the game but I'm happy with what I've been doing," Deduno said. "I was feeling pretty strong and was throwing the ball good."
Cleveland went up 2-0 in the third on a play scored as a rare sacrifice fly to second.
Stubbs singled leading off and went to third on Michael Bourn's single. With one out, Kipnis hit a flare to shallow center that second baseman Dozier ran down and caught behind the bag, but dropped as he was transferring the ball from his glove. Stubbs alertly stayed on the base, tagged and dashed home.
"That was an unbelievable piece of baserunning," Indians manager Terry Francona said. "He has no business scoring right there. The instincts to go on that and have the speed to match."
NOTES: Dozier's seven homers are a career high. He's batting .350 (7 for 20) with eight RBIs during a six-game hitting streak. "He's swinging," Gardenhire said. "When he gets that pitch he's cranking it pretty good." ... Twins 1B Justin Mourneau entered the series with 105 career RBIs against the Indians, his most against any club. ... The Twins have homered in six straight games. ... Despite the loss, the Twins are 13-6 against the Indians since last June.