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Using smell to detect cancer early on
Health: University of Oklahoma professor is developing a machine that sniffs out disease

 
By Vallery Brown | Published: August 15, 2008    Comment on this article Leave a comment

Dogs can smell cancer, researchers say, and a University of Oklahoma professor hopes he can someday build a machine with the same discriminating talent.

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Arnaud Sow, a University of Oklahoma graduate student from France, processes a sample for laser fabrication. This type of research allows engineers and researchers to make small nanoengineered materials. Photo provided by the University of Oklahoma
How would it work?

Patrick McCann's thesis is that biological compounds found in cancer patients can be detected on their breath with small laser sensors developed through nanotechnology.

Above, a molecular beam epitaxy system at the University of Oklahoma is shown.

The large machine is used to make the very small laser materials that McCann's research seeks to use in compact and low-cost breath meters for early cancer detection.

Nanotechnology is the creation of very small materials. Nano refers to a nanometer, which is a millionth of a millimeter. You need the highest-powered optical microscope to see nanotechnology features, McCann said.

Currently, molecular detection instruments made without nanotechnology are large and expensive, McCann said.

His plan is to develop a handheld machine that a person would breathe into and nanoengineered sensors would detect whether cancer-indicating compounds are present in the breath, and at what levels.

"We want to measure this, we just need a better instrument and this is where nanotechnology comes in,” McCann said.

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The device itself may be at least 10 years away.

The research hopefully will make early cancer detection more accurate and common, said lead researcher Patrick McCann, a professor of electrical and computer engineering at OU.

Many early detection methods sometimes cause adverse side effects that worsen a cancer patient's condition and still fail to spot cancer in its earliest stages.

"Our guide is the dogs, and the dogs are telling us that something is there,” said McCann, referring to research dating back as far as 1989 that links dogs' intense sense of smell to cancer detection.

When diseases such as cancer attack the body, there is often an increase in certain chemicals on the breath, said Bill Potter, a professor of biochemistry at the University of Tulsa who specializes in non-invasive diagnostics.

Many researchers are now studying this, Potter said, but it's what to measure that has been the problem.

"No one has a clear handle on the full suite, but there is a shift in metabolic patterns that give way to small molecules,” he said.

McCann hopes that further research in the medical field will help identify these possible early signs of cancer so that the machine he builds can detect them.

For now, it's the dog's nose that knows
Nicholas Broffman, executive director of the Pine Street Foundation, studies cancer detection and released research on the canine's ability to smell cancer in 2006.

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