The Warriors' bench outscored Detroit's 42-15. Golden State (35-22) is a season-high 13 games over .500.
Detroit (23-34) is fading from the playoff race in the Eastern Conference. The Pistons are now four games behind eighth-place Atlanta.
Josh Smith had 18 points, 11 rebounds and seven assists for Detroit but shot 9 of 24 from the field.
The first half was an entertaining one. Curry had a four-point play in the first quarter — just 40 seconds after Brandon Jennings had one for Detroit. There was also a dunk by Thompson on Singler that left the Detroit forward so off balance he fell into a row of cameramen near the basket.
NOTES: Michigan State coach Tom Izzo was seated courtside, and Spartans standout Adreian Payne was nearby. Draymond Green, a former star at Michigan State, had six points and five rebounds for Golden State. "Adreian will be here on this level in a few months, so it was good for him to get to see a game up close and be able to see me play," Green said. "It was also good to see Coach Izzo. Four years with him, it hasn't changed. He'll still call me and tell me what I'm doing wrong, and I'll call him and tell him what he's doing wrong." ... O'Neal and Detroit's Andre Drummond were hit with a double technical foul in the first quarter when they both went spilling into the same area for cameramen that Singler fell into. Green and Smith received technical fouls in the third, apparently for jawing at each other.