Then the Thunder put together a 17-5 run to end the half for a 57-42 advantage at the break. During the run, Durant had two driving dunks and Westbrook added a 3-pointer and four assists.
Oklahoma City opened the third quarter by extending its lead to 20 points as Westbrook scored nine points during a 13-8 start. The Thunder boosted their advantage to as many as 24 points in the second half on several occasions giving the Thunder the luxury of resting Durant and Westbrook.
"The first five minutes of the third quarter were probably the most important of the game," Westbrook said. "We wanted to come out and set the tone early defensively and we did a good job of that."
The Thunder were playing back-to-back games after defeating the Hawks Tuesday night in Atlanta.
The Thunder, who shot 61 percent in a win over Indiana on Sunday, shot 56 percent against the Grizzlies. Memphis shot 42 percent and was outrebounded, 42-33.
"The Thunder is a good team," Leuer said. "This is what they do. They go on runs. We tried to limit their easy stuff, but they got a few open looks and got into a rhythm after that."
NOTES: Thunder reserve center Steven Adams sprained his right ankle in the second half and didn't return. ... Grizzlies guard Tony Allen missed his fourth straight game with a right hip contusion and reserve forward Ed Davis missed his third straight with a left ankle sprain. ... The Thunder won for the first time this season on the second night of a back-to-back. They had been 0-2 in such games.