Kyle Lowry scored 10 for the Raptors, who had won four of their previous five home meetings with Oklahoma City. Jose Calderon had 10 points and 11 assists as Toronto dropped to 6-14 against Western Conference opponents.
Toronto guard Terrence Ross left one minute into the fourth quarter with a sprained left ankle and did not return. Casey said Ross' injury is not considered serious but declined to say whether the rookie would be available for Wednesday's game against Philadelphia.
Ibaka scored 10 points as the Thunder built a 23-12 lead with 3:10 left in the first, but Toronto closed the quarter with six straight points to make it 23-18 after one.
Anderson connected on his first six field goal attempts of the second quarter, including four 3-pointers, as the Raptors took a 39-37 lead with 5:40 left. Toronto kept it close the rest of the way, but a 3 by Thabo Sefolosha with 36 seconds left gave Oklahoma City a 52-50 edge at the half.
"That second quarter we were just exchanging baskets and when you do that, teams can get comfortable and teams can get hot," Brooks said.
Anderson and the Raptors cooled off in the third, making just five of 16 field goal attempts. Westbrook scored 12 points for the Thunder in the third as Oklahoma City pulled away again, taking a 78-67 lead into the fourth.
"In the second half we really locked in defensively," Brooks said. "Our length and athleticism causes a lot of problems."
NOTES: Toronto fell to 0-16 when allowing 100 points or more. ... This was the Thunder's first game north of the border since December, 2010. They did not visit the Raptors during the lockout-shortened 2011-12 season. ... Toronto C Aaron Gray (flulike symptoms) did not dress, with Johnson taking his place in the starting lineup. ... Raptors F Linas Kleiza (right knee) missed his fourth straight game. ... Former Buffalo Bills running back Thurman Thomas and former Raptors guard Muggsy Bogues attended the game.