Viciedo greeted Chen with a three-run shot to give the White Sox a 7-0 lead.
"I just couldn't find the strike zone," Guthrie said. "I created a mess in the first inning and gave up a bunch of base hits in the third."
Guthrie wound up allowing six runs on five hits and three walks in 2 1-3 innings, his shortest start since going the same distance for the Orioles on July 7, 2009. It was his second straight shaky outing, too — he allowed five runs over seven innings Saturday night at Tampa Bay.
All the more puzzling is that Guthrie had been having success against the White Sox. Since joining the Royals last year, the right-hander had been 3-0 in six starts against their AL Central rivals, giving up just two earned runs in 44 2-3 innings.
Guthrie had given up that many Friday night before escaping the first inning.
"He just didn't have it," Royals manager Ned Yost said. "It was one of those nights when he didn't have much going for him."
De Aza's two-run homer in the sixth made it 9-0, the most runs that the Royals' stingy pitching staff had allowed since an 11-6 loss to the New York Yankees on May 10. It was also the most runs the White Sox had scored since beating Toronto 10-6 on June 10.
"That's how this team is, going back to last year," Dunn said. "But you could see it, a little sigh of relief. You get a couple hits and you get a little excitement on the bench."
NOTES: The White Sox recalled RHP Brian Omogross from Triple-A Charlotte before the game. ... Major League Baseball announced the Royals will make up their May 2 game against Tampa Bay that was snowed out on Aug. 26 at Kauffman Stadium. The first pitch will be at 1:10 p.m. CT. ... LHP Jose Quintana takes the mound Saturday against Royals RHP Wade Davis.